Em. Olson et al., MR DETECTION OF WHITE-MATTER DISEASE OF THE BRAIN IN PATIENTS WITH HIV-INFECTION - FAST SPIN-ECHO VS CONVENTIONAL SPIN-ECHO PULSE SEQUENCES, American journal of roentgenology, 162(5), 1994, pp. 1199-1204
OBJECTIVE. Although fast spin-echo images and slower spin-echo images
have similar contrast characteristics, the two techniques have not yet
been shown to be equivalent in all aspects of brain imaging. To deter
mine if the two sequences are equivalent, we compared detection of whi
te matter lesions, image quality, and artifact degradation on fast spi
n-echo and spin-echo proton density-weighted and T2-weighted MR images
of the brain in prospectively selected patients who were sero-positiv
e for HIV. SUBJECTS AND METHODS. Fast spin-echo and spin-echo MR image
s of the brain were obtained in 153 consecutive subjects. The images w
ere reviewed independently by three experienced neuroradiologists. The
size, number, and location of white matter lesions were compared for
the two techniques. Image quality, motion artifact, CSF flow artifact,
and gray-white matter differentiation were graded on a five-point sca
le. RESULTS. No statistical difference was found in gray-white matter
differentiation. Overall image quality, CSF flow artifacts, and motion
artifacts were slightly worse on the fast spin-echo images (p < .05).
Although some variability existed in the detection of lesions less th
an 5 mm in diameter, the difference was small, and all larger lesions
were detected by both techniques. Agreement between fast spin-echo and
conventional spin-echo techniques was nearly exact with respect to ch
aracterizing findings in brain as either normal or abnormal.CONCLUSION
S. Fast spin-echo and spin-echo MR of the brain produce images of simi
lar quality and show white matter lesions equally well. These results
support the replacement of slower, conventional spin-echo pulse sequen
ces with faster fast spin-echo sequences.