ACIDOSIS AND GLUCOCORTICOIDS INDUCE BRANCHED-CHAIN AMINO-ACID CATABOLISM

Authors
ENGLAND BK GREWAL M BAILEY JL PRICE SR
Citation
Bk. England et al., ACIDOSIS AND GLUCOCORTICOIDS INDUCE BRANCHED-CHAIN AMINO-ACID CATABOLISM, Mineral and electrolyte metabolism, 22(1-3), 1996, pp. 69-71
Citations number
26
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Mineral and electrolyte metabolism → ACNP
ISSN journal
03780392
Volume
22
Issue
1-3
Year of publication
1996
Pages
69 - 71
Database
ISI
SICI code
0378-0392(1996)22:1-3<69:AAGIBA>2.0.ZU;2-O
Abstract
Chronic renal failure (CRF) is frequently complicated by malnutrition and wasting. The loss of lean body mass in CRF is the result of accele rated protein and amino acid degradation. Both appear to occur via aci dosis-induced, glucocorticoid-dependent processes. In skeletal muscle, acidosis stimulates the activity of the rate-limiting enzyme in branc hed-chain amino acid metabolism, branched-brain ketoacid dehydrogenase (BCKAD). The activation of BCKAD in acidosis is likely to be glucocor ticoid-dependent.