Jc. Harty et al., IS PERITONEAL PERMEABILITY AN ADVERSE RISK FACTOR FOR MALNUTRITION INCAPD PATIENTS, Mineral and electrolyte metabolism, 22(1-3), 1996, pp. 97-101
In light of the correlation between the dialysate to plasma ratio of c
reatinine (D/P Cr), peritoneal (PD) protein loss and hypoalbuminaemia,
peritoneal permeability has been implicated as a risk factor for maln
utrition in CAPD patients. However, serum albumin is also affected by
hydration which is itself influenced by peritoneal permeability. In a
cross-sectional study of 147 CAPD patients we investigated the relatio
nship between peritoneal permeability, PD protein loss and nutritional
state. Stepwise regression analysis revealed D/P Cr to be the only si
gnificant predictor of serum albumin independent of PD protein loss. N
o significant relationship was demonstrated between D/P Cr, body fat,
lean muscle mass and dietary protein intake. Increased peritoneal perm
eability does not cause hypoalbuminaemia as a consequence of increased
PD protein loss, and does not adversely affect somatic fat and protei
n status.