EFFECTS OF LOW-PROTEIN DIET SUPPLEMENTED WITH KETOACIDS ON PLASMA-LIPIDS IN ADULT CHRONIC-RENAL-FAILURE

We designed a short-term randomized controlled study in 12 adult patie nts with chronic renal failure to assess the metabolic effects of a lo w-protein diet (LPD) supplemented or not with ketoacids (Cetolog(R), C lintec Corp., France). Dietary survey included a monthly 3-day food re cord and a 24-hour urinary urea measurement. After a baseline period ( 1.11 g protein, 31.7 kcal/kg BW/day), patients reduced their protein i ntake (PI) to 0.71 g/kg BW/day. Energy intake (EI) was kept constant ( 31.4 kcal/kg BW/day) during the 3-month period, Baseline plasma lipids did not show overt hyperlipemia, After reducing PI, a significant inc rease in apolipoprotein AI and the Apo-AI/Apo-B ratio was observed. Pl asma Lp(a) levels were elevated at baseline and did not change during the 3-month LPD period. There was no difference between groups receivi ng ketoacids or not. Thus, in adult chronic renal failure, under a suf ficient EI, reducing PI by 40% had a beneficial effect on plasma lipid profile. This improvement in lipid profile might reduce the high card iovascular risk in these patients.