TAKING STOCK OF COMPLEX TRAIT GENETICS IN MICE

The mapping of complex trait loci in mice has recently become very pop ular thanks to dense genetic maps, better approaches to linkage analys is and the continued value of the mouse as a key model organism for hu man disease. Nevertheless, the ultimate goal remains very difficult: t o identify genes that underlie complex traits and to understand their function at a molecular level. In assessing the prospects of current e fforts, it helps to review the findings of earlier studies of complex traits and, despite all the technology, to be reminded of the inherent benefits and limitations at the source of genetic variation: the labo ratory mouse. with the right perspective it should be possible for gen eticists analysing complex traits to take full advantage of the resour ces that the genome project will provide.