ANTIMITOTIC AND ANTIVIRAL ACTIVITIES OF KELLETININ-A IN HTLV-1 INFECTED MT2 CELLS

Authors
SILVESTRI I ALBONICI L CIOTTI M LOMBARDI MP SINIBALDI P MANZARI V ORLANDO P CARRETTA F STRAZZULLO G GRIPPO P
Citation
I. Silvestri et al., ANTIMITOTIC AND ANTIVIRAL ACTIVITIES OF KELLETININ-A IN HTLV-1 INFECTED MT2 CELLS, Experientia, 51(11), 1995, pp. 1076-1080
Citations number
17
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
51
Issue
11
Year of publication
1995
Pages
1076 - 1080
Database
ISI
SICI code
0014-4754(1995)51:11<1076:AAAAOK>2.0.ZU;2-5
Abstract
Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural co mpound isolated from the marine gastropod Buccinulum corneum, showed a ntiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) a nd antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cel lular DNA and RNA synthesis, without influencing protein synthesis, an d interfered with viral transcription by reducing the levels of high m olecular weight transcripts. Finally, the compound inhibited HTLV-1 re verse transcriptase in vitro.