2 YEARS OF SYSTEMATIC MONITORING OF PREGN ANT-WOMEN EXPOSED TO DRUGS

Since 1990, the 'Centre Regional de Pharmacovigilance' of Nantes has s ystematically monitored pregnant women exposed to drugs. To increase p hysicians' participation in this study (34 per cent), the protocol was modified in 1992. Phoned answers are confirmed by mail. At the suppos ed time of the delivery, the physician receives a questionnaire about the outcome of pregnancy. A second letter and phone call are planned. With this method, 89 per cent of the pregnancies were fully documented between March 92 and March 94. Answers are classified according to th e type of the practice. Pregnancy outcome is studied according to the drugs and the moment of exposure during pregnancy. Quality of the info rmation, motivation of the physicians, and the benefits and difficulti es of this method are discussed.