Two cases of moderate neutropenia and 3 cases of severe neutropenia in
the course of fusidic acid treatment for sepsis related to a hip prot
hesis or septic osteitis are reported. Neutropenia was always observed
following routine blood cell count, after a mean of 21 days' treatmen
t (16 to 27 days). Moderate fever was observed only once, in a patient
with profound neutropenia. A complete recovery of blood cell count wa
s noted in all cases, 5 to 9 days upon discontinuation of fusidic acid
. A sternal bone-marrow aspiration was performed in 4 cases, showing n
ormocellularity or hypercellularity in two cases, and moderate hypopla
sia of granulocytic cells. The respective roles of other treatments ar
e discussed. Overall, these five cases suggest that reversible granulo
cytopenia can be caused by protracted treatment with fusidic acid. Alt
hough nine different associated drugs could also have been involved in
four patients, the causal relationship was less suggestive for three
of them due to chronological events. In other cases, the drugs never o
r very rarely caused neutropenia. Finally, the possibility of vancomyc
in-induced neutropenia cannot be excluded in one case.