ACPD LIGANDS FOR GLUTAMIC RECEPTORS - CONFORMATIONAL-ANALYSIS BY NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS - SIMULATION IN WATER OF GLUTAMIC-ACID ANALOGS CONTAINING A CYCLOPENTANE RING

The conformational analysis of two isomeric glutamic acid analogues ci s and trans ACPD containing a cyclopentane ring, was carried out in an aqueous environment, by H-1 and C-13 NMR spectroscopy, and molecular dynamics (MD) in water. These analogues interact on receptors of centr al nervous system (receptor metabotropic ACPD for the ligand trans ACP D and receptor ionotropic NMDA for the ligand cis ACPD). This study sh ow four conformational families I-IV with characteristic distances dl (alpha NH3(+) - gamma COO-) and d2 (alpha COO- - gamma COO-).