B. Magnadottir et al., STUDY OF THE HUMORAL RESPONSE OF ATLANTIC SALMON (SALMO-SALAR L), NATURALLY INFECTED WITH AEROMONAS-SALMONICIDA SSP ACHROMOGENES, Veterinary immunology and immunopathology, 49(1-2), 1995, pp. 127-142
The humoral antibody response of healthy Atlantic salmon and of two gr
oups of salmon, naturally infected with Aeromonas salmonicida ssp. ach
romogenes, was examined in some detail. One diseased group was chronic
ally infected and the other recently infected. It was found that the h
umoral response of these two infected groups was quite different. The
chronically infected fish showed poor specific response to the causati
ve agent whereas the recently infected salmon produced strong specific
antibody response. The chronically infected fish showed evidence of i
ncreased unspecific response including an elevated level of natural an
tibodies. The specific humoral response of the recently infected fish
was primarily directed against two cell-associated antigens of the A.
salmonicida ssp. achromogenes bacterium, the A-layer protein and the o
-polysaccharide component of LPS. In the chronically infected fish the
humoral response was primarily directed against the A-layer protein.