SYNTHESIS OF SOME 3'-(2-METHYL-1, 8-NAPHTHYRIDINE-3-CARBONYLAMINO)SPIRO[3H-INDOLE-3, 2'-THIAZOLIDINE]-2, 4'(1H)-DIONES AND 2-(2-METHYL-1, APH-THYRIDIN-3-YL)-[1,3,4]OXADIAZINO[5,6-B]INDOLES

Authors
RANI HS MOGILAIAH K RAO JS SREENIVASULU B
Citation
Hs. Rani et al., SYNTHESIS OF SOME 3'-(2-METHYL-1, 8-NAPHTHYRIDINE-3-CARBONYLAMINO)SPIRO[3H-INDOLE-3, 2'-THIAZOLIDINE]-2, 4'(1H)-DIONES AND 2-(2-METHYL-1, APH-THYRIDIN-3-YL)-[1,3,4]OXADIAZINO[5,6-B]INDOLES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(12), 1995, pp. 1035-1038
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
12
Year of publication
1995
Pages
1035 - 1038
Database
ISI
SICI code
0376-4699(1995)34:12<1035:SOS38>2.0.ZU;2-6
Abstract
Condensation of 2-methyl-1, 8-naphthyridine-3-carboxylic acid hydrazid e (1) with different isatins (2) gives the corresponding isatin-beta-( 2-methyl-1, 8-naphthyridin-3-carbonylhydrazones) (3), which on treatme nt with mercaptoacetic acid in DMF in the presence of anhyd. ZnCl2 aff ord the substituted 3'-(2-methyl-1, -naphthyridine-3-carbonylamino)spi ro-[3H-indole-3, 2'-thiazolidine]-2, 4' (1H)-diones (4). The hydrazone s 3 on treatment with Conc. H2SO4 undergo cyclodehydration to yield th e desired 2-(2-methyl-1, 8-naphthyridin-3-yl)-[1, 3, 4]oxadiazino[5, 6 -b]indoles (5). The compounds 4 and 5 have been tested for their biolo gical activity.