PLASMA AND INTESTINAL CONCENTRATIONS OF GIP AND GLP1(7-36)AMIDE DURING SUCKLING AND AFTER WEANING IN PIGS

Citation
Jme. Knapper et al., PLASMA AND INTESTINAL CONCENTRATIONS OF GIP AND GLP1(7-36)AMIDE DURING SUCKLING AND AFTER WEANING IN PIGS, Hormone and Metabolic Research, 27(11), 1995, pp. 485-490
Citations number
32
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
00185043
Volume
27
Issue
11
Year of publication
1995
Pages
485 - 490
Database
ISI
SICI code
0018-5043(1995)27:11<485:PAICOG>2.0.ZU;2-A
Abstract
Plasma concentrations of glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(7-36)amide (GLP-1[7-36]amide) were m easured after milk ingestion in 16 - 18 day old piglets and after wean ing diet ingestion in 33 day old piglets weaned at 21 days. Intestinal concentrations of these two hormones were also measured in unsuckled piglets of less than 24h of age, and piglets whose ages corresponded w ith those used for plasma measurements. Suckling piglets showed a mode rate glycaemic and insulinaemic response to milk ingestion. Plasma GIP and GLP-1(7-36)amide levels were significantly elevated at 1 and 3-h post-prandially. Weaned piglets showed a much more marked glucose and insulin response to meal ingestion. Plasma GIP and GLP-1(7-36)amide le vels were again significantly elevated at 1 and 3h in these animals. T he mean plasma GIP response was greater in the weaned animals compared with the suckling animals at the time points investigated. The plasma GLP-1(7-36)amide response in contrast was significantly greater at 1h in the suckling animals. In comparison, GIP concentrations in acid et hanol extracts of the small intestine were significantly higher during suckling and GLP-1(7-36)amide concentrations significantly higher aft er weaning. The circulating levels of both hormones seen during suckli ng and after weaning were far higher than those previously reported in humans. We conclude that both milk ingestion and the weaning diet are capable of stimulating CIP and GLP-1(7-36)amide in piglets and sugges t that the levels of both hormones seen in this study may be important in adipose tissue metabolism at this time.