SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF TAMOXIFEN CITRATE

Three simple and sensitive spectrophotometric methods for the determin ation of tamoxifen citrate have been developed. They are based on the formation of an ion-association complex between the drug and a dye, Er ioglaucine A, which is extractable into chloroform and has an absorpti on maximum at 625 nm (method A), oxidation with excess potassium perma nganate and the determination of unconsumed permanganate using Fast Gr een FCF (method B), or by the formation of a coloured cobalt thiocyant e coordination complex which is extracted into benzene and measured at 635 nm (method C). Beer's law limits for methods A, B, and C are 0.5- 3.0 mu g ml(-1), 1.0-6.0 mu g ml(-1) and 100-500 mu g ml(-1), respecti vely. No interference was observed from tableting additives and the ap plicability of the methods was examined by analysing tablets containin g tamoxifen. The quantities determined were 99.0-100.03% of the exptec ted values.