Vn. Gourine et al., HYPERTHERMIA-INDUCED BY FREUNDS COMPLETE ADJUVANT IN RATS AS AN EXPERIMENTAL-MODEL OF SLIGHT PROLONGED FEVER, Journal of thermal biology, 20(5), 1995, pp. 405-407
1. A single application of Freund's complete adjuvant (FCA) containing
killed and dried Mycobacterium butyricum to adult male and female whi
te rats led to the development of a hyperthermic response 2.5-3 h afte
r injection. 2. The duration of the response in experimental animals d
epended on ambient temperature. It lasted 1.5-2 days at 20-22 degrees
C or higher while it was more prolonged at 14-16 degrees C. The hypert
hermic response to FCA was not observed at temperatures below 10 degre
es C. 3. The dynamics of the temperature response allows us to divide
it into two phases. The first phase is characterized by an increase in
body temperature exceeding the control value by 1.2-1.4 degrees C in
the first day after injection. Then the response diminishes and subseq
uently differs from the control by 0.4-1.0 degrees C, which leads us t
o consider this phase as a slight prolonged fever (subfebrility).