EFFECTS OF INTRAVENOUS COCAINE ON PLASMA-CORTISOL AND PROLACTIN IN HUMAN COCAINE ABUSERS

The aim of the present work was to examine the cortisol and prolactin responses to acute cocaine administration in human cocaine users. Each subject served as his own control during intravenous saline placebo a nd cocaine (40 mg) infusion sessions, Cocaine significantly elevated p lasma cortisol but did not affect prolactin, The rise in cortisol coin cided with an increase in heart rate and blood pressure after cocaine, In agreement with studies in animals, our data suggest that cocaine a ctivates the hypothalamic-pituitary-adrenal axis in humans. However, b ased on the wed-known importance of dopamine as a prolactin-inhibiting factor, the failure of cocaine to suppress prolactin in the present s tudy raises questions concerning the role of dopamine in the mechanism of acute cocaine action in humans.