PREFERENTIAL INHIBITION OF INDUCIBLE NITRIC-OXIDE SYNTHASE BY EBSELEN

Authors
HATTORI R INOUE R SASE K EIZAWA H KOSUGA K AOYAMA T MASAYASU H KAWAI C SASAYAMA S YUI Y
Citation
R. Hattori et al., PREFERENTIAL INHIBITION OF INDUCIBLE NITRIC-OXIDE SYNTHASE BY EBSELEN, European journal of pharmacology. Molecular pharmacology section, 267(2), 1994, pp. 1-2
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology. Molecular pharmacology section → ACNP
ISSN journal
09224106
Volume
267
Issue
2
Year of publication
1994
Pages
1 - 2
Database
ISI
SICI code
0922-4106(1994)267:2<1:PIOINS>2.0.ZU;2-L
Abstract
Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially i nhibit the activity of inducible nitric oxide (NO) synthase with littl e inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vi vo studies to examine its possible application to the therapy of septi c shock where inducible NO synthase is responsible for vasodilation.