The use of vitamin B-6 supplements is widespread today. Doses used are
often elevated far above the physiological range and reach levels up
to 600-fold higher than recommended dietary allowances for healthy peo
ple. While the toxic effects caused by chronic high doses of vitamin B
-6 have been described earlier, pharmacokinetic data on vitamin B-6 su
pplements are rare. This article reviews the pharmacokinetic data of v
itamin B-6 from human subjects.