ANTITUSSIVE EFFECTS OF LEVODROPROPIZINE IN THE DOG

Authors
MUNT PL CLAVENNA G ALGATE DR LEACH RM
Citation
Pl. Munt et al., ANTITUSSIVE EFFECTS OF LEVODROPROPIZINE IN THE DOG, Arzneimittel-Forschung, 44-1(2), 1994, pp. 153-155
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-1
Issue
2
Year of publication
1994
Pages
153 - 155
Database
ISI
SICI code
0004-4172(1994)44-1:2<153:AEOLIT>2.0.ZU;2-M
Abstract
The antitussive activity of levodropropizine S(-)3-(4-phenyl-piperazin e-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate front which it is derived The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate.