ANTIINFLAMMATORY ACTIVITY OF ROLIPRAM IN A RAT EAR EDEMA MODEL

In the present study the anti-inflammatory activity of the phosphodies terase inhibitor rolipram (ZK 62 711, CAS 61413-54-5) was tested in a rat model were edema was induced in the ears of the animals by the epi cutaneous application of croton oil in ethanol (5%, by volume). The ad ministration of 0.015, 0.15 and 1.5 mg rolipram per ear dose-dependent ly inhibited the formation of edema. Concomitantly, the body temperatu re of the rats was decreased. 4-14% of rolipram was percutaneously abs orbed within a 5-h interval. The absorbed proportion, represented by t he area under the plasma level-time curve, correlated with the inhibit ion of edema formation and with the decrease in body temperature.