There is no effective medical treatment for primary sclerosing cholang
itis (PSC). Tamoxifen was found to have anti-fibrotic properties and h
as only few and rare side-effects. We gave 6 PSC patients 20 mg/day of
tamoxifen and we studied its influence on the alkaline phosphatase (A
LP) serum levels, Duration of treatment was from 1 to 8 months. Two pa
tients showed a decline of their ALP to normal values, the other 4 pat
ients showed improvement. Our results are encouraging and a larger sca
le study for a longer period of time is needed to evaluate the effect
of tamoxifen on PSC patients, In such a study, liver biopsies should b
e performed for histological evaluation.