In view of weak implication of immunoinflammatory mechanisms in pathog
enesis of noninflammatory nephropathy one may expect the disease cours
e improvement and more slow progression of renal dysfunction. The mech
anism of this action can be realized through hypolipidemic effect In r
ecent research there are data on a direct lovastatin action on the mec
hanism underlying nephritis progression by means of inhibiting prolife
ration of mesangial cells.