NUCLEATION OF MICROTUBULE ASSEMBLY BY A GAMMA-TUBULIN-CONTAINING RINGCOMPLEX

Authors
ZHENG YX WONG ML ALBERTS B MITCHISON T
Citation
Yx. Zheng et al., NUCLEATION OF MICROTUBULE ASSEMBLY BY A GAMMA-TUBULIN-CONTAINING RINGCOMPLEX, Nature, 378(6557), 1995, pp. 578-583
Citations number
36
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
378
Issue
6557
Year of publication
1995
Pages
578 - 583
Database
ISI
SICI code
0028-0836(1995)378:6557<578:NOMABA>2.0.ZU;2-P
Abstract
The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least sev en different proteins is seen to have an open ring structure. This com plex acts as an active microtubule-nucleating unit which can cap the m inus ends of microtubules in vitro.