COCHLEAR SYNAPTIC DEVELOPMENT AND MORPHOLOGY IN A GENETICALLY INDUCEDTYPE OF PROGRESSIVE HAIR CELL DEGENERATION

Authors
Citation
B. Sjostrom, COCHLEAR SYNAPTIC DEVELOPMENT AND MORPHOLOGY IN A GENETICALLY INDUCEDTYPE OF PROGRESSIVE HAIR CELL DEGENERATION, ORL, 56(3), 1994, pp. 119-124
Citations number
NO
Categorie Soggetti
Otorhinolaryngology
Journal title
ORLACNP
ISSN journal
03011569
Volume
56
Issue
3
Year of publication
1994
Pages
119 - 124
Database
ISI
SICI code
0301-1569(1994)56:3<119:CSDAMI>2.0.ZU;2-D
Abstract
In mice with genetically induced inner ear abnormalities it is conceiv able that in the morphogenetic types and in mutants with the spotting kind of pigmentary anomaly, the genes act through the developing nervo us system. It has been suggested that in degenerative (neuroepithelial ) mutants the influence of the gene is also reflected in the inner ear through the agency of the nervous system. The jerker mouse belongs to the neuroepithelial type of mutants which in homozygotes results in e arly postnatal degeneration of the sensory epithelium of the inner ear , initially confined to the cuticular plate and the stereocilia. In sp ite of well-advanced hair cell degeneration, these mutants developed m orphologically normal afferent and efferent nerve terminals at cochlea r hair cells.