FEVER IN UNCOMPLICATED PLASMODIUM-FALCIPARUM MALARIA - RANDOMIZED DOUBLE-BLIND COMPARISON OF IBUPROFEN AND PARACETAMOL TREATMENT

Authors
KRISHNA S PUKRITTAYAKAMEE S SUPANARANOND W TERKUILE F RUPRAH M SURA T WHITE NJ
Citation
S. Krishna et al., FEVER IN UNCOMPLICATED PLASMODIUM-FALCIPARUM MALARIA - RANDOMIZED DOUBLE-BLIND COMPARISON OF IBUPROFEN AND PARACETAMOL TREATMENT, Transactions of the Royal Society of Tropical Medicine and Hygiene, 89(5), 1995, pp. 507-509
Citations number
10
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
89
Issue
5
Year of publication
1995
Pages
507 - 509
Database
ISI
SICI code
0035-9203(1995)89:5<507:FIUPM->2.0.ZU;2-G
Abstract
Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-'blind' study, we compared a single dose of ib uprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8 for the tr eatment of fever > 38.5 degrees C due to uncomplicated falciparum mala ria. Ibuprofen was effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be con sidered as an antipyretic agent in the management of uncomplicated fal ciparum infections, providing there is no contraindication to its use.