CLOZAPINE TREATMENT OF PSYCHOSIS IN PATIENTS WITH TARDIVE DYSTONIA - REPORT OF 3 CASES

Among the tardive dyskinesia syndromes, dystonia can be the most diffi cult to treat. It may be severe to the point of being disabling, yet t he patients may require antipsychotic medications for an even more dis abling psychosis. Clozapine, an atypical neuroleptic drug that lacks e xtrapyramidal effects, may be the drug of choice for such patients. Th is report describes three patients with significant dystonia, previous ly disabled by their psychoses, who have been successfully managed wit h clozapine plus other agents for >3 years.