INCREASED ERYTHROPOIETIN PRODUCTION IN CHILDREN WITH SEVERE MALARIAL ANEMIA

Plasma immunoreactive erythropoietin concentrations were determined in 84 children with Plasmodium falciparum malaria in Gabon. There was an inverse log/linear relationship between hemoglobin or hematocrit and plasma erythropoietin, indicating that erythropoietin levels increased exponentially as circulating hemoglobin decreased. These results show that P. falciparum malaria does not lead to decreased erythropoietin production, and in turn reduced erythropoietin production does not con tribute to the pathogenesis of malarial anemia. There is an adequate r esponse of erythropoietin to anemia in children with P. falciparum mal aria.