EFFECT OF AMINO-ACIDS ON RAPAMYCIN BIOSYNTHESIS BY STREPTOMYCES-HYGROSCOPICUS

Authors
CHENG YR FANG A DEMAIN AL
Citation
Yr. Cheng et al., EFFECT OF AMINO-ACIDS ON RAPAMYCIN BIOSYNTHESIS BY STREPTOMYCES-HYGROSCOPICUS, Applied microbiology and biotechnology, 43(6), 1995, pp. 1096-1098
Citations number
10
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Applied microbiology and biotechnology → ACNP
ISSN journal
01757598
Volume
43
Issue
6
Year of publication
1995
Pages
1096 - 1098
Database
ISI
SICI code
0175-7598(1995)43:6<1096:EOAORB>2.0.ZU;2-C
Abstract
In a chemically defined medium containing aspartate, arginine and hist idine to support good growth, addition of L-lysine stimulated rapamyci n production by 150%. This was probably due to its conversion to pipec olic acid, a rapamycin precursor. Phenylalanine and methionine interfe red in rapamycin production by unknown mechanisms.