Yr. Cheng et al., EFFECT OF AMINO-ACIDS ON RAPAMYCIN BIOSYNTHESIS BY STREPTOMYCES-HYGROSCOPICUS, Applied microbiology and biotechnology, 43(6), 1995, pp. 1096-1098
In a chemically defined medium containing aspartate, arginine and hist
idine to support good growth, addition of L-lysine stimulated rapamyci
n production by 150%. This was probably due to its conversion to pipec
olic acid, a rapamycin precursor. Phenylalanine and methionine interfe
red in rapamycin production by unknown mechanisms.