URINARY-EXCRETION BY LEUCINAMINOPEPTIDASE AFTER EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY

Extracorporeal shock-wave lithotripsy (ESWL) is the treatment of choic e in the majority of urinary calculi. In experimental and clinical res earch it has been shown that the method has short-term deleterious eff ects on renal function. Several factors, such as urinary tract infecti on (UTI), the site of the stone, pre-existing renal abnormalities, the number and intensity of the shock waves may influence the extent of t he damage. The aim of this study was to measure the excretion of the r enal microsomal enzyme, leucinaminopeptidase (MLAP) as expression of r enal damage following ESWL. Our study shows that there was a significa nt elevation in urinary excretion of MLAP immediatly after ESWL, espec ially in patients with UTI. These results indicate that UTI may be one of the risk factors for aggravation of renal damage after ESWL. Howev er, these changes are transient and expresed less than in patients wit h light renal trauma arising because of other external influence.