ASSESSMENT OF PERFUSION WITH MYOCARDIAL P ERFUSION SCINTIGRAPHY AT APPLICATION OF CORONARY MEDICATION FOCUS ON THE PDE-III INHIBITOR ENOXIMONE

At a documented sensitivity of 75-90%, thallium-201 scintigraphy prove d to be the best noninvasive current screening method for the assessme nt of ischemic myocardial regions. The limited spatial resolution of a t best 1-2 cm allows only visualization of transmural perfusion and th us no differentiation between epi- and endocardial flow distribution. At exercise testing under betablockers, thallium extraction was surpri singly found unchanged or even reduced. After nitrates, a general norm alization of perfusion defects which had newly occurred under exercise is seen and thus a homogenization of perfusion distribution in myocar dial scintigraphy. At application of calcium antagonists, some authors have found a reduced poststenotic blood now in the perfusion scintigr aphy, others, in contrast, have found an increased blood flow in the p oststenotic ischemic region.