Depressive syndromes are the most common mental disorders among the ge
neral population. The scientific view concerning the prevalence and co
urse of depression, particularly with regard to the frequency of chron
icity and death by suicide, has changed during the last decade. Today
interest is focused on the problem of recurrent, chronic, and/or suici
dal depression. Diagnostic procedures center on the psychopathological
description of a ''depressive syndrome'' or ''depressive episode'' op
erationalized by number, duration and severity of symptoms according t
o ICD-10, in which etiological concepts such as ''neurotic'' or ''endo
genous'' depression are no longer used. However, such terms as ''react
ive'', ''neurotic'', or ''endogenous'' depression are still used now i
n daily psychiatric and psychological diagnostic and treatment strateg
ies. There is a growing consensus worldwide that a combination of psyc
hotherapeutic, biological and social treatment strategies is desirable
. In the first treatment phase a warm, empathetic patient-therapist re
lationship should be established (with the aim of acting against hopel
essness, preventing suicidal behavior, providing positive reinforcemen
t with regard to the patient's daily activity program, etc.). In a sec
ond phase, psychodynamic insight-oriented, cognitive, behavioral, and
family-oriented psychotherapies should be used. Antidepressants are re
commended for the control of symptoms.