TRANSCRIPTION AND NUCLEOTIDE EXCISION-REPAIR - REFLECTIONS, CONSIDERATIONS AND RECENT BIOCHEMICAL INSIGHTS

Recent years have witnessed considerable progress in the definition of the preferential repair of actively transcribed genes. Equally impres sive progress has been achieved in our understanding of the genetic an d biochemical complexity of the DNA-repair process called nucleotide e xcision repair (NER). Most recently studies in several laboratories ha ve yielded observations which provide insights about how the processes of transcription and NER may be linked in prokaryotic and eukaryotic cells.