POTENTIATION OF BLEOMYCIN BY THE AMINOTHIOL WR-1065 IN ASSAYS FOR CHROMOSOMAL DAMAGE IN G(0) HUMAN-LYMPHOCYTES

Authors
HOFFMANN GR SAYER AM LITTLEFIELD LG
Citation
Gr. Hoffmann et al., POTENTIATION OF BLEOMYCIN BY THE AMINOTHIOL WR-1065 IN ASSAYS FOR CHROMOSOMAL DAMAGE IN G(0) HUMAN-LYMPHOCYTES, MUTATION RESEARCH, 307(1), 1994, pp. 273-283
Citations number
35
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
307
Issue
1
Year of publication
1994
Pages
273 - 283
Database
ISI
SICI code
0027-5107(1994)307:1<273:POBBTA>2.0.ZU;2-4
Abstract
The aminothiol radioprotector WR-1065 potentiates the induction of chr omosome aberrations and micronuclei by the chemotherapy drug bleomycin in G(0) human lymphocytes. Potentiation by 5 mM WR-1065 was observed at bleomycin concentrations from 0.1 to 100 mu g/ml in a 2-h treatment . The frequencies of micronuclei induced by bleomycin in the presence of WR-1065 reached that of 500-fold higher concentrations of bleomycin alone. The potential therapeutic implications of these findings are d iscussed.