TREATMENT OF CHRONIC DISSEMINATED GEOTRICHUM-CAPITATUM INFECTION WITHHIGH CUMULATIVE DOSE OF COLLOIDAL AMPHOTERICIN-B AND ITRACONAZOLE IN A LEUKEMIA PATIENT

A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-che motherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil(TM ), 20.2 g in 11 weeks) and maintenance with itraconazole resolved clin ical manifestations of G. capitatum granulomatous disseminated disease and controlled reactivation of the infection during the two subsequen t courses of cytotoxic chemotherapy.