A 29 year-old woman with SLE was admitted to our department due to sev
ere remitting headaches, Following investigation a high degree of intr
a cranial pressure was determined, Several years ago a similar finding
was diagnosed, and the disease was brought into remission by the admi
nistration of periodical pulses of high dose intravenous immunoglobuli
ns, Benign intracranial hypertension (BIH) is an uncommon presentation
of neuropsychiatric SLE, In this patient several risk factors of BIH
(obesity; steroid therapy, and SLE) assembled and elicited a severe pr
esentation of the disorder which became more resistant to therapy, Sev
eral pathogenic pathways tie BIH with SLE as thrombotic obliteration o
f cerebral arteriolar and venous systems and immune complex deposition
within the arachnoid villi (that are responsible for CSF absorption),
As shown in this case report of BIH, clinical findings do not always
parallel various imaging techniques as MRI and CT brain scans.