NEW NEUROBLAST MARKERS AND THE ORIGIN OF THE ACC PCC NEURONS IN THE DROSOPHILA CENTRAL-NERVOUS-SYSTEM/

Drosophila is an ideal system for identifying genes that control centr al nervous system (CNS) development. Particularly useful tools include molecular markers for subsets of neural precursors (neuroblasts) and the simple expression pattern of the even-skipped (eve) gene in a subs et of neurons. Here we provide additional molecular markers for identi fied neuroblasts, including several with near single cell specificity. In addition, we use these new markers to trace the development of sev eral eve(+) neurons. Our results shows that the eve(+) aCC/pCC neurons develop from a different neuroblast than previously thought, and have led us to assign new names for several neuroblasts. These results are supported by DiI cell lineage analysis of neuroblasts identified in v ivo.