The aim of this study is to establish anatomical landmarks for the tra
jectory of the large septal artery, Thirty hearts were dissected, 20 o
f which had no cardiac pathology and the remaining with different card
iac conditions. One large septal artery was located in 27 of these hea
rts, two large septal arteries in 2 and three large septal arteries in
1, For all cases there existed one large septal artery in the lower h
erder of the anterior limb of the septomarginal trabecula, When more t
han one large septal artery was encountered, the first was located wit
hin the subendocardial outflow tract of the left ventricle, the second
was in the lower border of the anterior limb of the septomarginal tra
becula and the third 1.5 cm below the second.