PERTUSSIS TOXIN REVERSES THE INHIBITION OF THE ADENYLYL-CYCLASE SYSTEM BY KHELLIN IN HELA-CELLS

Authors
DISTEFANO A LAGAETANA R BOVALINI L LUSINI P MARTELLI P
Citation
A. Distefano et al., PERTUSSIS TOXIN REVERSES THE INHIBITION OF THE ADENYLYL-CYCLASE SYSTEM BY KHELLIN IN HELA-CELLS, Biochimica et biophysica acta. Molecular cell research, 1314(1-2), 1996, pp. 105-108
Citations number
20
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1314
Issue
1-2
Year of publication
1996
Pages
105 - 108
Database
ISI
SICI code
0167-4889(1996)1314:1-2<105:PTRTIO>2.0.ZU;2-#
Abstract
Khellin, a furochromone structurally related to furocoumarins, is a ph ototherapeutic agent used against psoriasis and vitiligo. This paper r eports that pretreatment of HeLa cells with pertussis toxin reverses b oth the inhibition of NaF-stimulated adenylyl cyclase activity and the stimulation of GTPase by khellin alone and plus UVA light, as previou sly reported. Our results demonstrate, for the first time, that khelli n is able to elicit an intracellular response by Gi alpha protein.