TISSUE-SPECIFIC BASAL EXPRESSION OF SOLUBLE MURINE EPOXIDE HYDROLASE AND EFFECTS OF CLOFIBRATE ON THE MESSENGER-RNA LEVELS IN EXTRAHEPATIC TISSUES AND LIVER

Authors
JOHANSSON C STARK A SANDBERG M EK B RASK L MEIJER J
Citation
C. Johansson et al., TISSUE-SPECIFIC BASAL EXPRESSION OF SOLUBLE MURINE EPOXIDE HYDROLASE AND EFFECTS OF CLOFIBRATE ON THE MESSENGER-RNA LEVELS IN EXTRAHEPATIC TISSUES AND LIVER, Archives of toxicology, 70(1), 1995, pp. 61-63
Citations number
15
Categorie Soggetti
Toxicology
Journal title
Archives of toxicology → ACNP
ISSN journal
03405761
Volume
70
Issue
1
Year of publication
1995
Pages
61 - 63
Database
ISI
SICI code
0340-5761(1995)70:1<61:TBEOSM>2.0.ZU;2-V
Abstract
The soluble epoxide hydrolase mRNA level in liver was increased eight- fold upon administration of the hypolipidemic drug and peroxisome prol iferator clofibrate for 7 days to mice. The soluble epoxide hydrolase mRNA was back at control levels within 1-2 days after clofibrate withd rawal. The highest expression was in liver, intestine and kidney. Lowe r levels were found in heart and muscle and very low levels were found in testes, lung, brain and spleen. The mRNA levels were increased in liver, kidney and heart by clofibrate.