IN-VITRO BIOTRANSFORMATION OF 2-METHYLPROPENE (ISOBUTENE) IN RAT LUNG-TISSUE IN COMPARISON WITH LIVER-TISSUE

Authors
CORNET M CALLAERTS A VERCRUYSSE A ROGIERS V
Citation
M. Cornet et al., IN-VITRO BIOTRANSFORMATION OF 2-METHYLPROPENE (ISOBUTENE) IN RAT LUNG-TISSUE IN COMPARISON WITH LIVER-TISSUE, Archives of toxicology, 70(1), 1995, pp. 64-67
Citations number
27
Categorie Soggetti
Toxicology
Journal title
Archives of toxicology → ACNP
ISSN journal
03405761
Volume
70
Issue
1
Year of publication
1995
Pages
64 - 67
Database
ISI
SICI code
0340-5761(1995)70:1<64:IBO2(I>2.0.ZU;2-P
Abstract
The epoxidation of the gaseous alkene 2-methylpropene or isobutene was studied in vitro in rat lung tissue in comparison with rat liver. Pul monary tissue appears to be less exposed to the toxic epoxide metaboli te than is the case for hepatic tissue. The results are correlated wit h the low capacity of the mixed function oxidase system, expressed by means of the cytochrome P-450 content and the 7-ethoxycoumarin O-deeth ylase activity, to form reactive intermediates. The activities of the principal epoxide detoxifying enzymes glutathione S-transferase and ep oxide hydrolase represent only 5-10% of the values measured in rat liv er.