POTENT ANTIMALARIAL ACTIVITY OF THE ALKALOID NITIDINE, ISOLATED FROM A KENYAN HERBAL REMEDY

Authors
GAKUNJU DMN MBERU EK DOSSAJI SF GRAY AI WAIGH RD WATERMAN PG WATKINS WM
Citation
Dmn. Gakunju et al., POTENT ANTIMALARIAL ACTIVITY OF THE ALKALOID NITIDINE, ISOLATED FROM A KENYAN HERBAL REMEDY, Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2606-2609
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
12
Year of publication
1995
Pages
2606 - 2609
Database
ISI
SICI code
0066-4804(1995)39:12<2606:PAAOTA>2.0.ZU;2-K
Abstract
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plan t used by the Pokot tribe of Kenya to treat fevers, has yielded the al kaloid nitidine as the major antimalarial component. Fractions contain ing nitidine have in vitro 50% inhibitory concentrations against Plasm odium falciparum in the range of 9 to 108 ng/ml for a range of chloroq uine-susceptible and -resistant strains. The results show a lack of cr oss-resistance between chloroquine and nitidine.