THALIDOMIDE INHIBITS LIPOARABINOMANNAN-INDUCED UP-REGULATION OF HUMAN-IMMUNODEFICIENCY-VIRUS EXPRESSION

Authors
PETERSON PK GEKKER G BORNEMANN M CHATTERJEE D CHAO CC
Citation
Pk. Peterson et al., THALIDOMIDE INHIBITS LIPOARABINOMANNAN-INDUCED UP-REGULATION OF HUMAN-IMMUNODEFICIENCY-VIRUS EXPRESSION, Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2807-2809
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
12
Year of publication
1995
Pages
2807 - 2809
Database
ISI
SICI code
0066-4804(1995)39:12<2807:TILUOH>2.0.ZU;2-I
Abstract
Mycobacterium tuberculosis accelerates the progression of human immuno deficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 express ion in U1 cells stimulated with mycobacterial lipoarabinomannans, supp ort the rationale behind conducting controlled trials of this immunomo dulatory agent with patients dually infected with HIV-1 and M. tubercu losis.