ENHANCED ACTIVITY OF THE COMBINATION OF PENICILLIN-G AND GENTAMICIN AGAINST PENICILLIN-RESISTANT VIRIDANS GROUP STREPTOCOCCI

Authors
CERCENADO E DIAZ MD SANCHEZCARRILLO C VICENTE T DEQUIROS JCLB
Citation
E. Cercenado et al., ENHANCED ACTIVITY OF THE COMBINATION OF PENICILLIN-G AND GENTAMICIN AGAINST PENICILLIN-RESISTANT VIRIDANS GROUP STREPTOCOCCI, Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2816-2818
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
12
Year of publication
1995
Pages
2816 - 2818
Database
ISI
SICI code
0066-4804(1995)39:12<2816:EAOTCO>2.0.ZU;2-9
Abstract
We evaluated the effects of the combination of penicillin G and gentam icin against 10 penicillin-resistant bacteremic isolates of viridans g roup streptococci for which the MICs of penicillin were 4 to 64 mu g/m l. In time-kill studies, the combination resulted in more killing of e ight isolates for which the MICs of penicillin were from 8 to 64 mu g/ ml than any of the antimicrobial agents tested alone, In general, clea rly enhanced antimicrobial activity was observed with the combination.