EFFECTS OF CHRONIC MANGANESE TOXICITY ON TISSUE-LEVELS AND URINARY-EXCRETION OF NICOTINAMIDE NUCLEOTIDES IN RATS

Authors
PATEL AB PANDYA AA
Citation
Ab. Patel et Aa. Pandya, EFFECTS OF CHRONIC MANGANESE TOXICITY ON TISSUE-LEVELS AND URINARY-EXCRETION OF NICOTINAMIDE NUCLEOTIDES IN RATS, Human & experimental toxicology, 13(5), 1994, pp. 307-309
Citations number
18
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
13
Issue
5
Year of publication
1994
Pages
307 - 309
Database
ISI
SICI code
0960-3271(1994)13:5<307:EOCMTO>2.0.ZU;2-Y
Abstract
Male rats were exposed to manganese sulphate i.p. daily for a period o f four weeks to see its effects on tissue levels and urinary excretion of total nicotinamide nucleotides (TNN). Increased levels of TNN were observed in blood and brain while the levels were found to be decreas ed in liver. There was a progressive increase in the excretion of TNN during the experimental period. TNN levels in blood and urine might se rve as useful biological indicators of Mn toxicity.