The flexible fibroscopic colonoscope has changed the way we approach c
olonic disease. The technique of safe, effective colonoscopy is discus
sed including the indications and contraindications for therapeutic in
tervention via the colonoscope. The techniques of polypectomy is descr
ibed, including some tips for methodology gained by the bread experien
ce of the author, and admonition against the possible complications wh
ich can be life-threatening. The application for polypectomy in the pr
esence of in-situ or invasive cancer is presented. The possible future
development of colonoscopic and laparoscopic techniques are presented
. The article concludes with a discussion of the monumental work of th
e National Polyp Study documenting that patients undergoing polypectom
y have a significant reduction in the incidence of colon cancer. Appli
cation of the knowledge to the general population requires the identif
ication of at-risk populations. (C) 1995 Wiley-Liss, Inc.