SUPERCRITICAL-FLUID EXTRACTION OF DRUGS IN DRUG-ADDICT HAIR

Opiates were extracted from sixteen hair samples of drug addicts using a supercritical fluid extraction method with supercritical carbon dio xide and a modifier solution of methanol-triethylamine-water (2:2:1, v /v). The concentrations, as determined by GC-MS, ranged from 1.22 to 2 1.73 (mean 7.60 ng/mg), 0.17 to 1,54 (mean 0.69 ng/mg) and 0.15 to 14. 09 ng/mg hair (mean 3.78 ng/mg) for codeine, morphine and 6-monoacetyl morphine, respectively. The reproducibility of the total procedure had a relative standard deviation of 13%, 17% and 14% for codeine, morphi ne and 6-monoacetylmorphine, respectively. By this method, concentrati ons of 0.3, 0.2 and 0.1 ng/mg hair for codeine, morphine and 6-monoace tylmorphine, respectively, could be detected. Relative extraction reco veries were 61%, 53% and 96% for codeine, morphine and 6-monoacetylmor phine, respectively.