The biologist Jacques Loeb is an important figure in the history of be
havior analysis. Between 1890 and 1915, Loeb championed an approach to
experimental biology that would later exert substantial influence on
the work of B. F. Skinner and behavior analysis. This paper examines s
ome of these sources of influence, with a particular emphasis on Loeb'
s firm commitment to prediction and control as fundamental goals of an
experimental life science, and how these goals were extended and broa
dened by Skinner. Both Loeb and Skinner adopted a pragmatic approach t
o science that put practical control of their subject matter above for
mal theory testing, both based their research programs on analyses of
reproducible units involving the intact organism, and both strongly en
dorsed technological applications of basic laboratory science. For Loe
b, but especially for Skinner, control came to mean something more tha
n mere experimental or technological control for its own sake; it beca
me synonomous with scientific understanding. This view follows from (a
) the successful working model of science Loeb and Skinner inherited f
rom Ernst Mach, in which science is viewed as human social activity, a
nd effective practical action is taken as the basis of scientific know
ledge, and (b) Skinner's analysis of scientific activity, situated in
the world of direct experience and related to practices arranged by sc
ientific verbal communities. From this perspective, prediction and con
trol are human acts that arise from and are maintained by social circu
mstances in which such acts meet with effective consequences.