Three packs of African wild dogs (Lycaon pictus) ranging to the north
of the Masai Mara National Reserve in southwestern Kenya were monitore
d from 1988 to 1990. During a six week period (August 2-September 14,
1989), 21 of 23 members of one of these packs died. Histological exami
nation of two brain samples revealed eosinophilic intracytoplasmic inc
lusions (Negri bodies), supporting a diagnosis of rabies viral encepha
litis. An additional brain sample tested positive for rabies with a fl
uorescent antibody test. Nucleotide sequence of the rabies viral N and
G genes from isolates of four African wild dogs (including an individ
ual from Tanzania) indicated that infection was with a viral variant c
ommon among domestic dogs in Kenya and Tanzania. A hypothesis linking
African wild dog rabies deaths to researcher handling is evaluated and
considered implausible.