QUANTIFICATION OF LIVER FLOOD VOLUME - COMPARISON OF ULTRA-SHORT TI INVERSION-RECOVERY ECHO-PLANAR IMAGING (ULSTIR-EPI), WITH DYNAMIC 3D-GRADIENT RECALLED ECHO IMAGING
Hc. Schwickert et al., QUANTIFICATION OF LIVER FLOOD VOLUME - COMPARISON OF ULTRA-SHORT TI INVERSION-RECOVERY ECHO-PLANAR IMAGING (ULSTIR-EPI), WITH DYNAMIC 3D-GRADIENT RECALLED ECHO IMAGING, Magnetic resonance in medicine, 34(6), 1995, pp. 845-852
An ultra-short TI inversion recovery echo-planar imaging (ULSTIR-EPI)
sequence was designed to reduce the influence of water exchange on fra
ctional tissue blood volume (BV) estimation by measurement of T-1-chan
ges induced by a gadolinium-based macromolecular contrast medium (MMCM
), Fractional liver BV in rats, estimated by ULSTIR-EPI was compared f
or accuracy to a fast T-1-weighted three-dimensional gradient-echo (3D
-SPGR, do-spoiled gradient recalled acquisition in a steady state) seq
uence using an in vitro inductively coupled plasma atomic emission spe
ctroscopy (ICP-AES) assay for BV as a standard, Liver images for fract
ional BV estimation were acquired in eight rats using both ULSTIR-EPI
and 3D-SPGR before and after (within 3 to 12 min) intravenous bolus ad
ministration of albumin-Gd-DTPA(30) (0.05 mmol Gd/kg), Whereas both MR
techniques may be useful for fractional tissue BV estimation, ULSTIR-
EPI offers certain advantages including greater accuracy, direct T-1 m
aps, and minimization of transendothelial proton exchange effects, 3D-
SPGR imaging offers better spatial resolution, current availability on
standard clinical MR systems, and acceptable accuracy.