Migraine is the most common neurological disorder, affecting about 20%
of adults. The mode of inheritance was analyzed in the two main types
of migraine, migraine without aura (MO) and migraine with aura (MA),
by complex segregation analysis using the computer program POINTER. We
included 126 probands with MO and 127 probands with MA from the gener
al population. First-degree relatives and spouses were blindly intervi
ewed by a neurological research fellow. The complex segregation analys
is indicated that both MO and MA have multifactorial inheritance witho
ut generational difference.