POLYMORPHIC TRINUCLEOTIDE AND TETRANUCLEOTIDE REPEATS IN EXON-1 AND EXON-8 OF THE MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) GENE

Polymorphic (CTC)n and (TAAA)n sequences were identified in exons 1 an d 8 of the myelin oligodendrocyte glycoprotein (MOG) gene. The differe nt alleles were detected by a method combining fluorescence labeling o f polymerase chain reaction (PCR) products and use of an automated DNA sequencer. Although only two alleles differing by the number of leuci ne residues encoded by the (CTC)n array were detected at the first loc us, seven alleles were identified at the second. The high degree of po lymorphism (75%) of the tetranucleotide repeat makes this marker infor mative for association or linkage studies with diseases such as hemoch romatosis or multiple sclerosis.